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Introduction

Modafinil is sold under the brand Provigil, which is a stimulant medication, a Schedule II controlled substance, and also a dopamine reuptake inhibitor used as a wakefulness-promoting agent.

It is a prescription medication mainly used to treat excessive sleepiness caused due to certain sleeping disorders like Narcolepsy and obstructive sleep apnea, and it also helps to treat shift work disorders.

Being a stimulant medication, Modafinil is generally safe to use, well tolerated, and carries a lower risk for abuse and dependence when used on a doctor’s prescription.

Modafinil is considered to have a high potential for abuse, misuse, and dependence. Therefore, it is subject to strict regulation and control. As a result, modafinil is only available on prescription and cannot be purchased over the counter.

It can decrease your sleepiness but it does not cure sleep disorders, you must continue to take it at the same time regularly and do not stop the use without your doctor’s recommendation. These medications can be habit-forming, avoid using it for more prolonged than prescribed.

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Why Modafinil Is Used?

  • Narcolepsy: Modafinil is a stimulant and eugeroic medication used primarily to treat Narcolepsy, a sleeping disorder that causes excessive sleepiness during the daytime, causing sudden sleep episodes/attacks.
  • Shift Work Disorder: It also helps people with shift work sleep disorder characterized by (sleepiness during waking hours and difficulty staying asleep during the scheduled sleeping hours) especially in people who work at night or on rotating shifts.
  • Obstructive Sleep Apnea: It helps people with sleep apnea with symptoms like (loud snoring, daytime sleepiness, and waking up gasping for air).

If you are taking Modafinil for shift work disorder, you need to take it one hour before your work shift begins. Take Modafinil at the same time everyday, do not change the time of taking the medication without consulting your doctor.

How It Works?

This medication works by changing the amount of certain natural chemicals in the area of the brain that controls sleep and improves wakefulness. It has also been shown to activate glutamate and inhibit GABA in these brain regions.

It also indirectly stimulates the release of norepinephrine and epinephrine hormones that activate the sympathetic nervous system.

It is not exactly known how modafinil works to manage sleep cycles or help people with narcolepsy, sleep apnea, and shift work disorder. However, it is believed that it may involve mimicking chemicals in your brain that act like adenosine and increase dopamine activity.

Who Cannot Take Modafinil?

Most of the adults suffering from narcolepsy, obstructive sleep apnea, and shift work disorder can use modafinil on prescription. However, in some cases, it is considered safe to use this medication, even on prescription.

You must avoid using Modafinil if you have any of these conditions such as –

  • Liver or kidney disease
  • Unusual allergic reaction to Modafinil
  • Have allergic reactions to any food, dyes, or preservatives
  • Pregnant or trying to conceive
  • History of depression, mania, or other mental disorders
  • Breastfeeding mother
  • Already using any stimulant medication

Side Effects Of Modafinil

Modafinil causes certain common to serious side effects that can sometimes be life-threatening, especially when not used as prescribed. It causes minor side effects such as headache, dizziness, nausea, Insomnia, and Anxiety.

Common Side Effects

  • Chills or fever
  • Confusion
  • Unsteadiness or clumsiness
  • Fainting
  • Blurry vision
  • Chest pain
  • Increased thirst and urination
  • Black stools

Serious Side Effects

  • Decreased appetite: This medication may lessen your appetite, which can result in weight loss.
  • Shortness of breath: Excessive use or taking it in inadequate amounts can affect your respiratory system, leading to slow, shallow, or shortness of breath.
  • Tremors: It causes rhythmic shaking of the head, arms, hand, and legs that causes difficulty in holding an object and writing.
  • Insomnia: that causes symptoms like difficulty in sleep initiation and staying asleep for a longer period of time.
  • Anxiety or depression: It can cause anxiety in a person by increasing wakefulness, and when a person stays awake for longer without having 7 – 8 hours of sleep, then it can lead to depression.
  • Allergic reactions: In some rare cases, it causes allergic reactions like itching, rashes, hives, or swelling of the face, lips, tongue, or throat.

Contact a doctor for immediate medical attention, if you experience any of these serious side effects to treat and manage them before worsening.

How To Use Modafinil Safely?

Modafinil is considered to have a higher potential for abuse, misuse, and addiction. To safely use this medication, you must avoid making these mistakes while using this medication.

  • Do not use this medication if you are taking birth control pills, as it may not work for you while using Modafinil.
  • Do not drink alcohol, as it can make you more dizzy and may interfere with the response of the medication.
  • Monitor for any side effects such as Hallucinations, delusions, aggression, mania, or suicidal thoughts.
  • Make sure to see the response of this medication before driving, using any machinery, or doing any activity that requires your alertness and focus.
  • Modafinil can heighten your anxiety at doses from 200 – 800 mg. Avoid using excess amounts of this medication.

Final Words

Modafinil can be used by anyone, especially those who wish to work late, stay awake, enhance their cognitive reactions, or want to brighten their mood.

Users of Modafinil may already be under a great level of stress, like cancer patients or battlefield soldiers.

A psychoneuroimmunological approach is still needed to investigate to understand multi-functional effects of Modafinil. You must use this medication on a doctor’s prescription and avoid sharing it with others without a doctor’s consultation, even if they have the same condition.

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